OASIS — Open Access Series of Imaging Studies

Overview

OASIS is a series of freely available MRI datasets focused on normal ageing and Alzheimer’s disease, produced by Washington University in St. Louis. Released incrementally since 2007, it was one of the earliest large open neuroimaging resources and remains widely used for methods development and dementia research.

Releases

• OASIS-1, released in 2007, provides cross-sectional structural MRI data from 416 participants aged 18–96, including subjects across the spectrum from normal ageing to moderate Alzheimer’s disease.
• OASIS-2, released in 2010, provides longitudinal structural MRI data from 150 participants aged 60–96 over two to four scan sessions.
• OASIS-3, released in 2019, is a longitudinal multimodal dataset from over 1,000 participants aged 42–95, covering T1, T2, FLAIR, ASL, and diffusion MRI alongside amyloid and tau PET, clinical assessments, and cognitive data spanning up to 30 years of follow-up per participant.
• OASIS-4 is an ongoing clinical cohort expansion with additional PET acquisition protocols.

Access

All data are freely accessible via XNAT Central (central.xnat.org) with free registration. There is no data use agreement and no cost. OASIS-3 is also mirrored on OpenNeuro.

Connections

• registeredIn: XNAT
• registeredIn: OpenNeuro

Resources

• https://www.oasis-brains.org
• https://central.xnat.org (XNAT Central access)
• https://doi.org/10.1162/jocn.2007.19.9.1498 (Marcus et al. 2007 — OASIS-1)
• https://doi.org/10.1523/JNEUROSCI.2914-19.2019 (LaMontagne et al. 2019 — OASIS-3)