All of Us Research Program

Overview

The All of Us Research Program is a longitudinal precision medicine cohort run by the National Institutes of Health. It supports research on many diseases, including neurological and psychiatric conditions such as Alzheimer’s disease. It links whole genome sequencing, electronic health records, survey, physical measurement, and wearable device data collected from enrolled participants. National enrollment opened in 2018, with participants recruited to include groups historically underrepresented in biomedical research. Electronic health record, survey, and physical measurement data are standardised to the OMOP Common Data Model, while wearable device and genomic data are held in separate, program-specific custom tables outside the core model. All data are made available to registered researchers through a cloud-based analysis environment.

Scale (2026)

• Participants: 883,000+, including 645,000+ from historically underrepresented communities
• Whole genome sequences released: 535,000+, linked to electronic health records for 482,000+ participants
• Proteomics data: 10,000+ participants
• RNA sequencing data: 9,000+ participants
• Long-read whole genome sequences: 14,500+ participants

Access

• The Registered Tier holds electronic health records, survey, and physical measurement data.
• The Controlled Tier adds whole genome sequencing, genotyping array, structural variant, and more granular demographic data.
• Access follows a data passport model based on researcher identity verification and institutional data use agreements, rather than per-project review.

Connections

• implements: OMOP CDM (for electronic health record, survey, and physical measurement data, with wearables and genomics held in separate custom tables outside the core model)

Resources

• https://allofus.nih.gov
• https://www.researchallofus.org
• https://www.nih.gov/news-events/news-releases/nihs-all-us-research-program-now-largest-integrated-genomics-health-database-world
• https://doi.org/10.1038/s41586-023-06957-x
• https://support.researchallofus.org/hc/en-us/articles/360033200232-Data-Dictionaries (confirms custom, non-OMOP tables for wearables and genomics)