PGC — Psychiatric Genomics Consortium
Overview
The Psychiatric Genomics Consortium is a global consortium conducting genome-wide association studies of psychiatric and neurodevelopmental disorders. Its working groups cover conditions including major depressive disorder, bipolar disorder, schizophrenia, autism, ADHD, PTSD, OCD, Tourette syndrome, and Alzheimer’s disease. Founded in 2007, it coordinates more than 800 investigators across dozens of countries. As of 2026, it has aggregated genomic and phenotypic data from over 900,000 participants, expanding the known genetic architecture of psychiatric illness. Working groups publish summary statistics openly and route individual-level data through controlled-access repositories. Dedicated working groups extend its genomic coverage to African, Latin American, and South Asian ancestries.
Data and access
- Genome-wide association summary statistics from published analyses are freely downloadable without approval, subject to acknowledgement and citation requirements.
- Individual-level genotype and phenotype data for most cohorts is accessed through dbGaP, including a dedicated PGC collection that gathers the relevant accessions in one place.
- Imputation across analyses commonly references the Haplotype Reference Consortium panel, accessed through a specific dataset in EGA.
- Analysis code and quality control documentation for published papers are maintained on the consortium’s GitHub organisation.
Connections
- registeredIn: dbGaP
- relatedTo: EGA (the Haplotype Reference Consortium imputation panel used across PGC analyses is accessed via a specific EGA dataset)