ReDLat — Multi-Partner Consortium to Expand Dementia Research in Latin America
Overview
ReDLat (Multi-Partner Consortium to Expand Dementia Research in Latin America) is a regional research consortium studying the genetic and social determinants of Alzheimer’s disease and frontotemporal dementia across Latin American populations that are under-represented in global dementia research. Launched in 2019 as a five-year initiative funded by the US National Institutes of Health and National Institute on Aging, the Alzheimer’s Association, the Rainwater Charitable Foundation, and the Global Brain Health Institute, it recruits a first-in-class cohort of over 4,000 participants from Argentina, Brazil, Chile, Colombia, Mexico, Peru, and the United States. ReDLat combines genomic, neuroimaging, clinical, cognitive, and socioeconomic data under harmonized recruitment and assessment procedures, and its open neuroimaging output is released through the BrainLat institute as the multimodal BrainLat dataset. It produces the harmonization framework and regional research agenda that several Latin American open-data efforts build on, and operates within the regional dementia-research ecosystem coordinated by the Latin America and the Caribbean Consortium on Dementia (LAC-CD) and supported by the Global Brain Health Institute (GBHI).
Data and harmonization
ReDLat collects genomic, neuroimaging (anatomical MRI, resting-state fMRI, diffusion-weighted MRI), clinical, cognitive, and socioeconomic data across its sites. Recruitment and neurocognitive assessment follow harmonized ReDLat procedures documented in a site manual, a checklist, and a tutorial, so that data collected in different countries can be pooled and compared. The neuroimaging and cognitive component of this effort is openly released as the BrainLat dataset (780 participants across five countries) through the BrainLat institute, while genomic and clinical data follow controlled-access routes appropriate to their sensitivity.
Connections
- relatedTo: BrainLat (ReDLat and BrainLat jointly led the multimodal BrainLat dataset; BrainLat releases the open neuroimaging component)
Resources
- https://www.gbhi.org/projects/multi-partner-consortium-expand-dementia-research-latin-america-redlat
- https://doi.org/10.3389/fneur.2021.631722 (Ibanez et al. 2021, Frontiers in Neurology — ReDLat overview)
- https://doi.org/10.3233/JAD-201384 (Ibanez et al. 2021, JAD — LAC-CD and ReDLat networking-to-implementation)