Banque ADN et Cellules — ICM DNA and Cell Bank
Overview
The Banque ADN et Cellules is Paris Brain Institute’s biological resource centre (BRC) for neurological disease research, hosted at ICM as one of its 10 core technological platforms. It collects, processes, stores, and distributes biological resources including DNA, RNA, cells, CSF, plasma, and iPSCs from patients with neurological disorders and healthy controls. The bank supports ICM research teams and external academic and industrial collaborators in accessing biological material for neurogenomics, biomarker discovery, and translational research.
Biological Resources Collected
- Germline genomic DNA from neurological disease patients including Alzheimer’s, Parkinson’s, ALS, MS, and rare neurological diseases.
- Total and mRNA RNA for transcriptomics studies.
- Primary cell cultures, lymphoblastoid cell lines (LCLs), and fibroblasts from patients.
- Induced pluripotent stem cells (iPSCs) derived from patient fibroblasts or blood, differentiated into neurons, astrocytes, and oligodendrocytes.
- Cerebrospinal fluid (CSF) samples from lumbar punctures for biomarker studies.
- Plasma and serum samples linked to clinical and imaging data.
- Post-mortem brain tissue samples (selected cases).
Quality and Certification
- Operates under the French biobank regulatory framework (Code de la Sante Publique Articles L. 1243-3 ff.).
- CNIL-authorised for biological sample collection and data management.
- ISO 20387 certified (international standard for biobanking quality management).
- IBiSA-labelled (national platform quality label for French biology/health infrastructure).
Connections
- Hosted at: Paris Brain Institute
- Regulatory framework: Code de la Sante Publique
- Biobank networks: BBMRI-ERIC
- Labelled by: IBiSA
- Downstream platform: iGENSEQ