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Paris Brain Institute

Overview

The Paris Brain Institute (Institut du Cerveau, ICM) is a non-profit neuroscience research foundation established in 2010 at Pitié-Salpêtrière University Hospital in Paris. Co-governed by Sorbonne Université, CNRS, Inserm, and AP-HP, it brings together more than 800 researchers and clinicians on a single site combining fundamental research, clinical neurology, and translational science. Research is organised around five scientific axes: neurodegenerative diseases, glial disorders and repair, neuronal excitability, cognition and emotion, and clinical translation. The institute operates 10 core technological platforms shared across research teams. Originally named Institut du Cerveau et de la Moelle Épinière, it was renamed Paris Brain Institute in 2020.

Core Facilities

ICM operates 12 core technological platforms:

  • CENIR provides multimodal human neuroimaging (MRI 3T/7T, PET-MRI, MEG, EEG, TMS, stereotaxy).
  • CATI is a national neuroimaging data management centre for multisite cohort studies.
  • ICM.Quant provides quantitative microscopy (widefield, confocal, STED, light-sheet, TEM).
  • HISTOMICS covers histology, neuropathology, and spatial transcriptomics (10x Visium, Xenium, NanoString GeoMx).
  • iGENSEQ provides next-generation sequencing (WGS, WES, bulk and single-cell RNA-seq, ddPCR).
  • Banque ADN et Cellules is a neurological disease biobank (DNA, RNA, cells, CSF, plasma).
  • ICV handles cell engineering and vectorology (iPSC generation; AAV, lentivirus, and adenovirus vector production).
  • ePHYS provides preclinical electrophysiology (patch-clamp, MEA, Neuropixels in vivo recording, video-EEG).
  • PRISME covers behavioural phenotyping and cognitive assessment.
  • DAC provides bioinformatics, data management, and statistical analysis.
  • The RnD Unit handles custom scientific instrumentation design and fabrication (F.P.Journe Charity Fund).
  • A proteomics platform

Clinical Research Infrastructure

  • CIC Neurosciences (Inserm CIC-1422) is the Inserm and AP-HP clinical trial platform at Pitié-Salpêtrière, running approximately 80 studies per year and operating as an ECRIN node via F-CRIN.
  • iCRIN is the translational clinical research programme, organised around 13 disease-area themes and backed operationally by CIC Neurosciences.

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