HPA — Human Protein Atlas
Overview
The Human Protein Atlas is a Swedish open-access programme initiated in 2003 to map the spatial distribution of all human proteins in cells, tissues, and organs using antibody-based imaging, transcriptomics, and proteomics. All data are freely available under a Creative Commons Attribution licence. The programme is coordinated by KTH Royal Institute of Technology and Uppsala University within the SciLifeLab national infrastructure ecosystem and is a designated ELIXIR Core Data Resource. Its Brain Atlas section maps protein expression across human, pig, and mouse brain, covering genome-wide expression profiles for 17,832 genes across 56 annotated expression clusters in the human brain alone. Version 25.1, released in May 2026, added Deep Visual Proteomics data to the single-cell resource. The HPA is a widely used open reference atlas for spatial protein expression in brain tissue and a direct complement to single-cell transcriptomics portals in the brain cell atlas ecosystem.
Connections
- endorsedBy: ELIXIR (designated ELIXIR Core Data Resource via SciLifeLab/NBIS as ELIXIR-SE)
- isPartOf: SciLifeLab (HPA is produced within the SciLifeLab national infrastructure ecosystem)
- relatedTo: CELLxGENE (complementary single-cell transcriptomics atlas; cross-referenced at cell-type level)
- relatedTo: Allen Institute for Brain Science (parallel brain atlas role; spatial expression cross-referencing)