ADNI — Alzheimer’s Disease Neuroimaging Initiative

Overview

ADNI is a longitudinal multicenter study tracking MRI, PET, biomarkers, clinical, and genetic data across the Alzheimer’s disease spectrum. Launched in 2004 and now in its fourth phase (ADNI4), it is a widely used open resource for Alzheimer’s disease research.

Key Outputs

• ADNI has enrolled over 2,000 participants across phases ADNI1, GO, 2, 3, and 4 as of 2024.
• Data types include MRI, amyloid, tau, and FDG PET, CSF, genetics, and cognitive data.
• Imaging protocols are harmonised across North American sites.

Access

Data are distributed through the LONI Image and Data Archive. Access requires free registration and approval of a data use agreement, with each study phase maintaining its own access conditions. There is no cost to researchers.

Connections

• registeredIn: LONI IDA
• registeredIn: ClinicalTrials.gov

Resources

• https://adni.loni.usc.edu
• https://adni.loni.usc.edu/data-samples/access-data/ (data access portal)
• https://adni.loni.usc.edu/study-design/ (study design overview)
• https://doi.org/10.1016/j.jalz.2010.03.004 (Jack et al. 2010 — ADNI design paper)