ADNI — Alzheimer’s Disease Neuroimaging Initiative

Overview

ADNI is a longitudinal multicenter study tracking MRI, PET, biomarkers, clinical, and genetic data across the Alzheimer’s disease spectrum. Launched in 2004 and now in its fourth phase (ADNI4), it provides openly shared data for Alzheimer’s disease research.

Key Outputs

• ADNI has enrolled over 2,000 participants across phases ADNI1, GO, 2, 3, and 4 as of 2024.
• Data types include MRI, amyloid, tau, and FDG PET, CSF, genetics, and cognitive data.
• Imaging protocols are harmonised across North American sites.

Access

Data are distributed through the LONI Image and Data Archive. Access requires free registration and approval of a data use agreement, with each study phase maintaining its own access conditions. There is no cost to researchers.

Connections

• registeredIn: LONI IDA
• registeredIn: ClinicalTrials.gov

Resources

• https://adni.loni.usc.edu
• https://adni.loni.usc.edu/data-samples/access-data/ (data access portal)
• https://adni.loni.usc.edu/study-design/ (study design overview)
• https://doi.org/10.1016/j.jalz.2010.03.004 (Jack et al. 2010 — ADNI design paper)